The Power of GENETICS
Extending the power of DNA into small molecule drug generation
Empress makes small molecule drug discovery more predictable and efficient by accessing superior drug starting points from chemistry encoded in DNA.
A vast and untapped opportunity
The solution to faster drug discovery is inside of us
The amount of genetic material that encodes instructions for biosynthesis of small molecules in commensal DNA is massive, equivalent to 50% of the human genome.
Until now, this universe has never been systematically explored, mapped to therapeutic opportunities and mined for new medicines.
DNA encodes chemistry
Genetic code programs cells in the human body to produce chemistry in the form of metabolites.
Advances in genomics, AI, and synthetic biology now allow us to “read” this code sourced from patient samples and systematically identify, decode, and use these biosynthetic instructions to make small molecule drugs fast.
Co-evolution selects drug leads
The molecules made inside our bodies today are the sum result of innumerable evolutionary experiments across millennia.
Biosynthetic DNA reveals instructions for making potent, selective chemistries that are human compatible and important for maintaining health and treating or preventing disease.
DNA encodes proteins that synthesize small molecules
Human
Genome
Biosynthetic
Metagenome
The biosynthetic metagenome is equivalent to 50 percent of the human genome.
proteins
DNA encodes proteins, specifically enzymes, that make or modify small molecules.
molecules
Countless small molecules made and tested by Nature in the human body to maintain human health.
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Benefits
Created by co-evolution, refined by life
Human compatibility
We sample from quadrillions of small molecules that are made, modified, and play important roles within the human body.
Co-validation
We leverage genetics to discover Co-Evolved MedicinesTM as well as their mechanisms and disease relevance.
Broad therapeutic potential
Comparing patient data from health and disease allows us to map chemistry to therapeutic potential. These molecules can be found throughout the body, showing the potential to address a wide variety of diseases.
